Introduction: A Strategy for Overcoming the Definitional Struggle

Genecialist manifesto: overcoming the “class struggle” in medicine

Generalists and specialists are often considered two completely distinct species, which culminates in the establishment of a concept of dichotomy. However, these dichotomy can at times fuel tension and even erupt into open conflict. In order to resolve this issue, the author herein proposes the concept of a "genecialist." The genecialist refers to a hybrid comprising elements inherent to both g...

A Short Introduction to Clinical Photography for the Plastic Surgeon

Overcoming the inhibitors of myelin with a novel neurotrophin strategy.

Myelin inhibitors activate a p75(NTR)-dependent signaling cascade in neurons that not only inhibits axonal growth but also prevents neurotrophins (NT) from stimulating growth. Most intriguingly, in addition to Trk receptors, neurotrophins also bind to p75(NTR). We have designed a "mini-neurotrophin" called B(AG) to activate TrkB in the absence of p75(NTR) binding. We find that B(AG) is as effec...

A Definitional Metalanguage for Explanatory Combinatorial Lexicography

How are lexical senses described? One can identify two main families of sense descriptions on the basis of their relation to word meaning: word paraphrases vs. word interpretations. The first family can itself be subdivided into three main subfamilies, according to the formal nature of sense descriptions. 1. Word paraphrases 1.1. " Standard " lexicographic definitions are, roughly speaking, lin...

The Struggle for Existence

"It is in the nature of things" is surely, today, just as good an explanation of a biological phenomenon as it ever was; and now, as always, it is singularly unilluminating. That some of the problems to which such an explanation is usually given are susceptible to analysis appears obvious; at least an approach can be made toward segregating the many factors which, acting independently ox throug...